Imagine heading off on vacation without the nagging worry of an overflowing inbox. If you lack an assistant to handle communications, a well-crafted out-of-office (OOO) autoresponder is your best ally. As someone who's managed high-volume inboxes for years—processing over 500 emails daily while maintaining Inbox Zero—I've perfected this process. Here's my expert guide to setting up Gmail's autoresponder and preparing your email for time away.
Start by lightening your load. Communicate your absence in advance: update your email signature with vacation dates. For deeper strategies, check out 6 Ways to Reclaim Your Email Inbox or harness the power of personalized email signatures.
This preemptive step reduces incoming floods. Adopt the Inbox Zero flowchart from Maintaining Inbox Zero Daily With This Flowchart: delete irrelevancies, delegate tasks, handle quick items under two minutes, and list longer ones.

Unsubscribe from newsletters using tools outlined in Clean Up Your Inbox – Quickly Unsubscribe from Multiple Newsletters.
Even with warnings, emails will arrive. Your autoresponder reinforces your absence. Key elements:
Access it via the gear icon > Settings > General tab, scroll to Vacation responder. Set dates, compose in rich text or plain, and check Only send a response to people in my contacts. Gmail auto-deactivates on the end date.

For personalized handling, use filters alongside the responder. First, enable forwarding: Settings > Forwarding and POP/IMAP > Add a forwarding address. Confirm with your colleague.
Create filters: Use search options (e.g., from: sender or keywords). Click Create filter, select Forward it to and apply labels for tracking.


Alternatives: Canned responses, as detailed in Email Faster and Better with Canned Responses.
Test everything with a secondary email. Schedule a return task to disable responders and filters. Follow Steve Dotto's full procedure for reliability.
Upon return:
This works in Thunderbird (How to Configure Mozilla Thunderbird for Autoresponders) and Outlook too. Share your tips or questions in the comments!